职称：讲师

E-mail：xyzhao@stu.edu.cn

赵鑫悦博士于2025年在厦门大学获得博士学位。于2026年6月加盟汕头大学，现任汕头大学工学院生物医学工程系讲师。

研究兴趣

肿瘤微环境响应型诊疗探针的设计、制备及应用；新型靶向共价药物的设计、合成及应用

教育背景

2021.09–2025.06 厦门大学化学化工学院，分析化学，博士学位

2018.12–2021.06 西北大学化学与材料科学学院，分析化学，硕士学位

2014.09–2018.06 南京师范大学教师教育学院，化学师范，学士学位

工作经历

2026.06 -至今 汕头大学工学院生物医学工程系讲师

2025.07–2026.06 厦门大学化学化工学院博士后

科研项目

汕头大学科研启动经费项目，在研，2026.07-2029.06

科研论文

1. Xinyue Zhao, Yuxin Gu, Yingyan Xie, Naijie Wei, Ziyang Fang, Xiaowen Yan*, Qiuquan Wang. A BTK-activatable targeted covalent NIR fluorescent probe for kinase monitoring and B-cell lymphoma imaging. Biosensors and Bioelectronics. 2025, 289, 117867. (SCI一区, IF: 11.8)

2. Xinyue Zhao^#, Naijie Wei^#, Ziyang Fang, Yingyan Xie, Xiaowen Yan*, Qiuquan Wang. A Targeted Covalently Activated Chemotherapy Strategy Synergistically Enhances Cytotoxicity of Ibrutinib and Selectivity of Doxorubicin to B-cell Lymphoma Cells. Journal of Medicinal Chemistry. 2026, 69 (3), 2387−2399. (SCI一区, IF: 7.3)

3. Xinyue Zhao^#, Lulu Ning^#, Xiaoman Zhou, Zhihui Song, Jianjian Zhang*, Feng Guan, and Xiao-Feng Yang. An Activatable Near-Infrared Fluorescence Hydrogen Sulfide (H₂S) Donor for Imaging H₂S Release and Inhibiting Inflammation in Cells. Analytical Chemistry, 2021, 93, 4894−4901. (SCI一区, IF: 7.3)

4. Ziyang Fang^#, Xinyue Zhao^#, Ruxue Hou^{#, Yang Zhao, Lei Wang, Li Yi, Limin Yang, Xiaowen Yan*, Qiuquan Wang. Antibody-Directed Cell Internalization of Targeted Covalent Europium Tag Enables in Situ Kinase Labeling and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Quantification. Analytical Chemistry. 2025, 97, 12125−12132. (SCI一区, IF: 7.3)}

5. Xinyue Zhao^#, Yang Zhao^#, Ziyang Fang^#, Naijie Wei, Jianbin Chen, Qiuquan Wang, and Xiaowen Yan*. Antibody-Targeted Covalent Inhibitor Conjugate (Ab-TCI) Bridged by an Arsenic-Thiol Bond Enables “Double Insurance” Targeting of Cancer Cells and Kinase for Effective Cancer Treatment. ACS Medicinal Chemistry Letters. 2026, 17, 5, 1195–1201. (SCI二区, IF: 3.9)

专利

1. 发明专利：一种硫化氢供体、制备方法及其应用，张健健;赵鑫悦;宁璐璐;杨小峰，CN113480458B. (已授权)

2. 发明专利：一种抗体靶向共价药物偶联物及其制备方法和应用, 严晓文;赵鑫悦，CN121971645A.

3. 发明专利：一种靶向共价激活前药化合物及其制备方法和应用, 严晓文;赵鑫悦;王秋泉，CN121574168A.

教学工作

本科生教学科目Undergraduate Course：Biomedical Engineering Undergraduate Laboratory