1. Therapeutic effects and mechanisms of stem cells and EVs in neurological diseases

2. Association between novel environmental pollutants and neurological diseases

Dr. Shaowei Guo is a supervisor for Master’s students and post-doctoral fellows, as well as an international co-supervisor for Ph.D. students. Dr. Guo graduated from Shantou University Medical College (SUMC) and the Technion – Israel Institute of Technology. He was mentored by Prof. Shulamit Levenberg from the Faculty of Biomedical Engineering at the Technion where he focused on stem cells, neural tissue engineering and regeneration. Upon completing his Ph.D. program at the Technion, Dr. Guo returned to the First Affiliated Hospital (FAH) of SUMC to dedicate himself to clinical practice, scientific research, and teaching. Over the past few years, he has published 14 papers in international journals such as Lancet Ebiomedicine, Nano Letters, ACS Nano, Advanced Healthcare Materials, and Biotechnology Advances, with an accumulative impact factor of over 150. Part of his research achievements has been translated into the NurExone company.

Email: 07swguo1@stu.edu.cn

Education

2015-2020: Faculty of Biomedical Engineering, Technion – Israel Institute of Technology (PhD)

2007-2014: Shantou University Medical College, 7-year program in Clinical Medicine

Work Experience

2023-present: Dept. of Neurology, FAH of SUMC (Associate Researcher/Attending Physician)

2020-2022:    Dept. of Neurology, FAH of SUMC (Resident)

2014-2015:    Dept. of Neurology, FAH of SUMC (Resident)

Research Fields

1. Neural tissue engineering；

2. Novel pollutants and neurotoxicity

Current Projects

1. National Natural Science Foundation of China Youth Fund Project, “Effects and mechanisms of three-dimensional BMEC-primed iPSC-NSPCs on reconstituting spinal circuits after spinal cord injury”

2. Natural Science Foundation of Guangdong Province, “Effects and mechanisms of miR-21-3p from M2 microglia derived exosomes on regulating the differentiation of spinal cord derived neural stem cells and reconstituting spinal circuits after spinal cord injury”

3. GuangDong Basic and Applied Basic Research Foundation, “Effects and mechanism of human dental pulp stem cell derived extracellular vesicles regulating NLRP3 inflammasome for promoting spinal cord injury repair”

4. Li Ka Shing Foundation Cross-disciplinary Project, “Hybrid stem cell- or exosome-microchip for advanced therapy of central nervous system injuries”

Publications

1. Wang T, Yi Z, Liu X, Cai Y, Huang X, Fang J, Shen R, Lu W, Xiao Y, Zhuang W, Guo S. Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites. Lancet EBioMedicine, 2024. (IF: 11.1)

2. Wang T, Huang G, Yi Z, Dai S, Zhuang W, Guo S. Advances in extracellular vesicle-based combination therapies for spinal cord injury. Neural Regeneration Research, 2023. (IF: 6.1)

3. Debbi L*, Guo S*, Safina D, Levenberg S. Boosting extracellular vesicle production. Biotechnology Advances, 2022. (IF: 16.0)

4. Guo S*, Debbi L*, Zohar B, Samuel R, Arzi R, Fried A, Carmon T, Shevach D, Redenski I, Schlachet I, Sosnik A, Levenberg S. Stimulating extracellular vesicles production from engineered tissues by mechanical forces. Nano Letters, 2021. (IF: 10.8)

5. Guo S, Redenski I, Levenberg S. Spinal cord repair: from cells and tissue engineering to extracellular vesicles. Cells, 2021. (IF: 6.0)

6. Redenski I*, Guo S*, Machour M, Szklanny A, Landau S, Egozi D, Gabet Y, Levenberg S. Microcomputed Tomography-based analysis of neovascularization within bioengineered vascularized tissues. ACS Biomaterials Science and Engineering, 2021. (IF: 5.8)

7. Redenski I, Guo S, Machour M, Szklanny A, Landau S, Kaplan B, Lock R, Gabet Y, Vunjak-Novakovic G, Levenberg S. Engineered vascularized flaps, composed of polymeric soft-tissue and live-bone, repair complex tibial defects. Advanced Functional Materials, 2021. (IF: 19.0)

8. Frisch A, Debbi L, Shuhmaher M, Guo S, Levenberg S. Advances in vascularization and innervation of constructs for neural tissue engineering. Current Opinion in Biotechnology, 2021. (IF: 7.7)

9. Guo S*, Redenski I*, Landau S, Szklanny A, Merdler U, Levenberg S. Prevascularized scaffolds bearing human dental pulp stem cells for treating complete spinal cord injury. Advanced Healthcare Materials, 2020. (IF: 10.0)

10. Kaplan B, Merdler U, Szklanny A, Redenski I, Guo S, Mucha Z, Michael N, Levenberg S. Rapid prototyping fabrication of soft and oriented polyester scaffolds for axonal guidance. Biomaterials, 2020. (IF: 14.0)

11. Guo S, Perets N, Betzer O, Ben-Shaul S, Sheinin A, Michaelevski I, Popovtzer R, Offen D, Levenberg S. Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury. ACS Nano, 2019. (IF: 17.1)

12. Szklanny A, Debbi L, Merdler U, Neale D, Muniz A, Kaplan B, Guo S, Lahann J, Levenberg S. High-throughput scaffold system for studying the effect of local geometry and topology on the development and orientation of sprouting blood vessels. Advanced Functional Materials, 2019. (IF: 19.0)

13. Landau S, Guo S, Levenberg S. Localization of engineered vasculature within 3D tissue constructs. Frontiers in Bioengineering and Biotechnology, 2018. (IF: 5.7)

14. Ganz J, Shor E, Guo S, Sheinin A, Arie I, Michaelevski I, Pitaru S, Offen D, Levenberg S. Implantation of 3D constructs embedded with oral mucosa-derived cells induces functional recovery in rats with complete spinal cord transection. Frontiers in Neuroscience, 2017. (IF: 4.3)

Teaching

1. Neurology, at SUMC

2. Principles and Practice of Medicine, at SUMC

3. Scientific Reasoning in Medicine, at SUMC

4. Human Anatomy and Physiology, at STU