Benqing Zhou
Associate professor
PHD
Novel nanomaterials design and their applications in tumor precise diagnosis and therapy.
Dr. Benqing Zhou's research interests are the design of new biomaterials for cancer theranostics. At present, he has published more than 40 SCI papers, of which 25 are the first and corresponding authors (4 are IF > 10 points). The papers have been cited more than 1700 times, and the H-index is 22. Has applied for 13 national invention patents, of which 7 have been authorized. He has presided over 6 scientific research projects, including 4 projects above the provincial and ministerial level. Serves as an Editorial Board Member of the Journal of Functional Biomaterials (IF=4.8, JCR-Q2) and as a reviewer for several journals.
E-mail：bqzhou@stu.edu.cn
Education
2007.9-2011.7 Anhui Normal University, Bachelor Degree
2011.9-2017.3 Donghua University, Doctor Degree
Work Experience
2017.1-2019.4, Postdoctoral Researcher, Shenzhen University
2019.5-now, Associate Professor, Department of Biomedical Engineering, School of Engineering, Shantou University
Academic Services
2014.9-2014.10 University of Debrecen (exchange visit)
2015.5-2015.8 University of Madeira (exchange visit)
2017.10-2018.10 University of Central Oklahoma (exchange visit)
Research
The design of new biomaterials for cancer theranostics.
Current Projects
1. National Natural Science Foundation of China Youth Fund Project, 61805161, Research on the mechanism of targeted tumor chemotherapy and hyperthermia with two dimensional black phosphorus nanosheets based on FLIM/PA composite imaging precision monitoring, 2019/01-2021/12, 250,000 RMB;
2. Special Funding Project of China Postdoctoral Science Foundation, 2018T110890, FLIM/PA Imaging Analysis of Cancer Precision Monitoring and Treatment based on black phosphorus nanosheets, 150,000 RMB;
3. Project sponsored by China Postdoctoral Science Foundation, 2017M622766, Research on Targeted chemotherapy/hyperthermia for Cancer Accurately monitored by FLIM and PA Imaging, 50,000 RMB;
4. Project of Natural Science Foundation of Guangdong Province, 2021A1515010441, Construction of CD146 Targeted photothermal immune hybrid nanomedicine and its application in the precise Targeted Treatment of Triple-negative breast Cancer, 2021-01-2023/12,100,000 RMB;
5. Research Start-up Fund of Shantou University, 09419027, Photothermal immunotherapy for Cancer based on two-dimensional Black scale nanosheets, 2019/05-2022/051.2 million RMB;
6. Li Ka-shing Foundation Cross-project, 54620305, Application research of CD146 targeted photothermal immune hybrid nanomaterials in the precision treatment of triple-negative breast cancer, 2020/07-2023/07,1 million RMB.
Publications
1. Jinxing Liu, Chong Zhao, Wei R. Chen, Benqing Zhou*, Recent progress in two-dimensional nanomaterials for cancer theranostics, Coordination Chemistry Reviews, 2022, 469, 214654 (IF=24.833).
2. Libin Huang, Chaoran Xie, Zixia Wu, Man Ji, Jia Shan, Pei Cheng, Jianming Liu, Luya Chen, Benqing Zhou*, Wenjie Sun*, Lateral size homogeneous and doping degree controllable potassium-doped graphene quantum dots by mechanochemical reaction, Chemical Engineering Journal, 2022, 135800 (IF=16.744).
3. Benqing Zhou, Jinxing Liu, Meiai Lin, Jingyi Zhu, Wei R. Chen, Recent advances in immunotherapy, immunoadjuvant, and nanomaterial-based combination immunotherapy, Coordination Chemistry Reviews, 2021, 442, 214009 (IF=24.833).
4. Benqing Zhou, Qiang Wu, Meng Wang, Ashley Hoover, Xin Wang, Feifan Zhou, Rheal A. Towner, Nataliya Smith, Debra Saunders, Jun Song, Junle Qu, Wei R. Chen. Immunologically modified MnFe2O4 nanoparticles to synergize photothermal therapy and immunotherapy for cancer treatment, Chemical Engineering Journal, 2020, 396, 125239 (IF=16.744).
5. Benqing Zhou, Ruizhi Wang, Feng Chen, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai, Qiang Ouyang, Xiangyang Shi, and Mingwu Shen. 99mTc-labeled RGD-polyethylenimine conjugates with entrapped gold nanoparticles in the cavities for dual mode SPECT/CT imaging of hepatic carcinoma, ACS Applied Materials & Interfaces, 2018, 10, 6146-6154 (IF=10.383).
6. Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li Jingchao Li, Shihui Wen, Mingwu Shen, Guixiang Zhang, Xiangyang Shi. Synthesis and characterization of PEGylated polyethylenimine-entrapped gold nanoparticles for blood pool and tumor CT imaging, ACS Applied Materials & Interfaces, 2014, 6, 17190-17199 (IF=10.383).
7. Benqing Zhou, Jinxing Liu, Lu Wang, Meng Wang, Chong Zhao, Haoyu Lin, Yuanke Liang, Rheal A Towner, Wei R Chen, Iron oxide nanoparticles as a drug carrier reduce host immunosuppression for enhanced chemotherapy, Nanoscale, 2022,14(12), 4588-4594 (IF=8.307).
8. Benqing Zhou, Jun Song, Meng Wang, Xin Wang, Jielin Wang, Eric W. Howard, Feifan Zhou, Junle Qu and Wei R Chen. BSA-bioinspired gold nanorods loaded with immunoadjuvant for treatment of melanoma by combined photothermal therapy and immunotherapy, Nanoscale, 2018, 10(46), 21640-21647 (IF=8.307).
9. Chong Zhao, Benqing Zhou*, Polyethyleneimine-Based Drug Delivery Systems for Cancer Theranostics, Journal of Functional Biomaterials, 2023, 14(1), 12 (IF=4.901).
10. Sheng Zhao, Liang He, Yihao Sun, Ting Xu, Chunmei Chen, Yi Ouyang, Yan Chen, Yixin Tan, Benqing Zhou*, Hui Liu*, Acid-responsive drug-loaded copper phosphate nanoparticles for tumor cell therapy through synergistic apoptosis and ferroptosis strategy, Journal of Nanoparticle Research, 2023, 25(1), 7 (IF=2.533).
11. Chunmei Chen, Wei Zhang, Shi-Yu Lu, Jingjing Wang, Yixin Tan, Sheng Zhao, Yi Ouyang, Luen Xu, Benqing Zhou*, Xuntao Yin*, Haitao Ran*, Hui Liu*, Repolarizing tumor-associated macrophages by layered double hydroxide-based deacidification agent for tumor chemodynamic therapy and immunotherapy, Colloids and Surfaces B: Biointerfaces, 2023, 223, 113157 (IF=5.999).
12. Benqing Zhou, Lingzhou Zhao, Mingwu Shen, Jinhua Zhao, Xiangyang Shi. A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo, Journal of Materials Chemistry B, 2017, 5, 1542-1550 (In 2017 Journal of Materials Chemistry B HOT Papers, IF=7.571).
13. Zhe Wang, Yili Zhao, Mingwu Shen, Helena Tomás, Benqing Zhou*, Xiangyang Shi*, Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers, Journal of Functional Biomaterials, 2022, 13, 55 (IF=4.901).
14. Di Yin, Andrew Shi, Benqing Zhou*, Mengyuan Wang, Gangwei Xu, Mingwu Shen, Xiaoyue Zhu*, and Xiangyang Shi*, Efficient Capture and Separation of Cancer Cells Using Hyaluronic Acid-Modified Magnetic Beads in a Microfluidic Chip, Langmuir, 2022, 38, 36, 11080-11086 (IF=4.331).
15. Jingyi Zhu, Pingping Zhao, Junxing Yang, Jianhui Shi, Jianlin Chu,Wenjun Miao, Yili Zhao and Benqing Zhou*. Sharpening upconversion nanoparticles to reduce surface quenching, Dalton Transactions, 2020,49, 285-288 (IF=4.569).
16. Benqing Zhou, Zhijuan Xiong, Peng Wang, Chen Peng, Mingwu Shen, and Xiangyang Shi. Acetylated Polyethylenimine-Entrapped Gold Nanoparticles Enable Negative Computed Tomography Imaging of Orthotopic Hepatic Carcinoma, Langmuir, 2018, 34 (29), 8701-8707 (IF=4.331).
17. Benqing Zhou, Zuogang Xiong, Jianzhi Zhu, Mingwu Shen, Guangyu Tang, Chen Peng, Xiangyang Shi. PEGylated polyethylenimine-entrapped gold nanoparticles loaded with gadolinium for dual mode CT/MR imaging applications, Nanomedicine, 2016, 11(13), 1639-1652 (IF=6.096).
18. Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng, Mingwu Shen, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi. Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium, Drug Delivery, 2018, 25(1), 178-186 (IF=6.891).
19. Benqing Zhou, Mingwu Shen, István Bányai, Xiangyang Shi. Structural characterization of PEGylated polyethylenimine-entrapped gold nanoparticles: an NMR study, Analyst, 2016, 141, 5390-5397 (IF=5.227).
20. Benqing Zhou, Jia Yang, Chen Peng, Jianzhi Zhu, Yueqin Tang, Xiaoyue Zhu, Mingwu Shen, Guixiang Zhang, Xiangyang Shi. PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging, Colloids and Surfaces B: Biointerfaces, 2016, 140, 489-496 (IF=5.999).
21. Rania Mustafa#, Benqing Zhou#, Jia Yang#, Guixiang Zhang, Xiangyang Shi. Dendrimer-functionalized laponite nanodisks loaded with gadolinium for T1-weighted MR imaging applications, RSC Advances, 2016, 6, 95112-95119 (IF=4.036).
22. Fanfan Fu#, Benqing Zhou#, Zhijun Ouyang, Yilun Wu, Jingyi Zhu, Mingwu Shen, Jindong Xia, Xiangyang Shi, Multifunctional cholesterol-modified dendrimers for targeted drug delivery to cancer cells expressing folate receptors, Chinese Journal of Polymer Science, 2019, 37(2), 129-135 (IF=3.815).
23. Xin Yuan, Benqing Zhou*, Maoquan Li, Mingwu Shen and Xiangyang Shi*, Colorimetric detection of Cr3+ ions in aqueous solution using poly(γ-glutamic acid)-stabilized gold nanoparticles, Analytical Methods, 2020, 12, 3145-3150 (IF=3.532).
Patents
1. Shi Xiangyang, Zhou Benqing, Peng Chen, Zhang Guixiang, Zheng Linfeng, a polyethylene-modified hyperbranched polyethylene-imide coated gold nanoparticles preparation method, China Patent for Invention, Patent No. ZL201310193203.2, License Announcement Date: 2015-05-13 (authorized).
2. Shi Xiangyang, Zhou Benqing, Zhang Guixiang, Yang Jia, Peng Chen, a folate targeted multifunctional hyperbranched polyethylenimide coated gold nanoparticles preparation method, China Patent for Invention, Patent No. ZL2014104876861.1, License Announcement Date: 2017-01-04 (authorized).
3. Shi Xiangyang, Sun Wenjie, Zhu Jianzhi, Li Jingchao, Zhou Benqing, Shen Mingwu, Preparation method of sodium alginate nanogel supported by iron oxide nanoparticles, China Patent for Invention, Patent No. : ZL 201510023466.8, License Announcement Date: 2017-10-24 (authorized).
4. Shi Xiangyang, Chen Chen, Zhou Benqing, Preparation method of multifunctional branched polyethylenimide drug carrier targeting hyaluronic acid, China Patent for Invention, Patent No. ZL201510487046.5, License Announcement Date: 2018-04-20 (authorized).
5. Shi Xiangyang, Zhou Zhou Wei, Zhou Benqing, Sun Wenjie, Hu Yong, Preparation method of γ-PGA nanohydrogel loaded with polyaniline, China Patent for Invention, Patent No. ZL2017100767290, License Announcement Date: 2020-04-21 (authorized).
6. Shi Xiangyang, Wang Peng, Hu Yong, Zhou Benqing, Xu Fanli, Zhang Guixiang, Yang Jia, a zwitterionic modified multi-functional Mn3O4 nanoparticle magnetic resonance imaging contrast agent and its preparation and application, China Patent for Invention, Patent No. ZL 2016108885337, License Announcement Date: 2020-05-29 (authorized).
7. Zhou Benqing, Zhao Chong, a two-dimensional black phosphorus hybrid nanomide targeting HER2-positive breast cancer based on PEG-MAL modification, China Invention Patent, Patent No. 202210413458.4, Announcement Date: 2020.06.09 (authorized).
8. Shi Xiangyang, Zhou Benqing, Preparation method of hyperbranched polyvinyl imide nanoprobe modified by RGD polypeptide, China Patent for Invention, Application No. 201710136134X, Application date: 2017-03-08.
9. Shi Xiangyang, Zhu Jianzhi, Sun Wenjie, Zhou Benqing, Zhou Zhouwei, Peng Chen, Preparation method of γ-PGA hydrogel loaded with Au nanoparticles, China Patent for Invention, Application No. 201610068698X, Application date: 2016-01-29.
10. Shi Xiangyang, Zhou BenQing, Tang Guangyu, Peng Chen, Fu Fanfan, a preparation method of CT/MR Dual-mode imaging contrast agent based on hyperbranched polythene imide molecule, China Patent for Invention, Application No. 2014104689140, Application date: 2014-09-15.
11. Shi Xiangyang, Zhou Benqing, Zhao Jinhua, Zhao Lingzhou, a folate-targeted multifunctional hyperbranched polythyleneimide loading doxorubicin method, China Invention Patent, Application No. 2016104209250, Application date: 2015-06-14.
12. Zhou Benqing, Liu Jinxing, a hybrid ferrimanganic oxide nano-drug modified by OVA protein and its preparation method, China Invention Patent, Application No. 2020101180596, Application date: 2020.02.26.
13. Zhou Benqing, Liu Jinxing, Zhao Chong, a cell counting method based on Calcein AM/PI double staining cell fluorescence image, China Invention Patent, Application No. 202210698019.2, Application date: 2022.06.20
Te Teaching
1. Undergraduate teaching subjects: Design and Application of Biomaterials, Physics for Biomedical Engineering (thermodynamics), Biomedical Undergraduate Lab (cell experiments)
2. Postgraduate teaching subjects: Advances in biomedical engineering
Positions in academic institutions or Professional Affiliations
Serves as an Editorial Board Member of the Journal of Functional Biomaterials (IF=4.8, JCR-Q2).
Honors and Awards
1. 2021 Outstanding Party Member of Shantou University
2. Excellent head Teacher of Shantou University in 2022
3. 2023 Guide college students to win the bronze Award of the 9th China International 4) "Internet +" College Student Innovation and Entrepreneurship Competition in Guangdong Province
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