癌症基因组学、生物信息学、模式识别

沈文君，毕业于香港城市大学计算机科学系；斯坦福大学访问学者。现为汕头大学医学院生物信息教研室，副教授、硕士生导师。主要研究方向包括癌症基因组学、生物信息学和模式识别，在Foundations of Computational Mathematics，Journal of Experimental & Clinical Cancer Research, Cell Reports Methods,  Cancers, Frontiers in Microbiology, Knowledge-Based Systems, Pattern Recognition等重要期刊上发表论文20余篇。

代表性论文

1、Wen-Jun Shen#, Hau-San Wong, Quan-Wu Xiao, Xin Guo and Stephen Smale*,“Introduction to the Peptide Binding Problem of Computational Immunology: New Results,” Foundations of Computational Mathematics, 14(5), pp951-984, 2013 .

2、Wen-Jun Shen#, Fan Zhang, Xing Zhao and Jianzhen Xu*, “LncRNAs and Esophageal Squamous Cell Carcinoma - Implications for Pathogenesis and Drug Development,” Journal of Cancer, 7(10):1258, 2016.

3、Wen-Jun Shen#, Wenjuan Cui, Danze Chen, Jieming Zhang and Jianzhen Xu*. RPiRLS: Quantitative Predictions of RNA Interacting with Any Protein of Known Sequence. Molecules, 2018, 23(3): 540.

4、Wen-Jun Shen#*, Xun Zhang, Shaohong Zhang, Cheng Liu, and Wenjuan Cui. The Utility of Supertype Clustering in Prediction for Class II MHC-Peptide Binding. Molecules, 2018, 23(11): 3034.

5、Wenjun Shen#*, Guoyun Wang, Georgia R. Cooper, Yuming Jiang*, and Xin Zhou. The Epithelial and Stromal Immune Microenvironment in Gastric Cancer: A Comprehensive Analysis Reveals Prognostic Factors with Digital Cytometry. Cancers 2021, 13, 5382.

6、Zihang Wen, Jeremy L. Langsam, Lu Zhang, Wenjun Shen*, and Xin Zhou*. A Bayesian factorization method to recover single-cell RNA sequencing data. Cell Reports Methods. 2022, 2(1):100133.

7、Guoyun Wang, Cheng Lv, Cheng Liu, Wenjun Shen*. Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting influenza susceptibility. Front Microbiol. 2022 Oct 6;13:1003380.

8、Xiaoyang Huo, Xiangping Zeng, Si Wu*, Wenjun Shen*, Hau-San Wong. Collaborative Learning with Unreliability Adaptation for Semi-Supervised Image Classification. Pattern Recognition. 2022, 133: 109032.

9、Quanpeng Song, Guanyue Li, Si Wu*, Wenjun Shen*, Hau-San Wong. Discriminator feature-based progressive GAN inversion. Knowledge-Based Systems. 2023, 261:110186.

10、Jian-Zhong He#, Yang Chen#, Fa-Min Zeng#, Qing-Feng Huang#, Hai-Feng Zhang, Shao-Hong Wang, Shuai-Xia Yu, Xiao-Xiao Pang, Ye Liu, Xiu-E Xu, Jian-Yi Wu, Wen-Jun Shen*, Zhan-Yu Li*, En-Min Li*, Li-Yan Xu*. Spatial analysis of stromal signatures identifies invasive front carcinoma-associated fibroblasts as suppressors of anti-tumor immune response in esophageal cancer. J Exp Clin Cancer Res. 2023 May 31;42(1):136.

科研项目

沈文君-国家自然科学基金青年基金：MHC多肽结合位点鉴定及超类型识别(Project No. 61502292)

沈文君-广东省基础与应用基础研究基金自然科学基金项目（青年提升项目）：基于最优传输和单细胞转录组测序研究肿瘤浸润淋巴细胞的空间异质性(Project No. 2023A1515030154)

主讲课程

转录组数据分析、应用生物信息学