郭少维
副研究员
1. 干细胞及外泌体对神经再生的效应及机制研究；
2. 新型环境污染物与神经系统疾病的关联
郭少维医生是硕士生导师、中外联培博士生导师、博士后合作导师。郭医生毕业于汕头大学医学院和以色列理工学院生物医学工程系。博士阶段师承Shulamit Levenberg教授，专注于干细胞及神经组织再生研究；毕业后返回汕头大学医学院第一附属医院从事临床、科研和教学工作。近年来，在国际知名期刊发表14篇SCI论文，包括Lancet Ebiomedicine, Nano Letters, ACS Nano, Advanced Healthcare Materials, Biotechnology Advances等，累计影响因子超过150分。科研成果成功转化为NurExone科技公司。
教育背景
2015-2020： 以色列理工学院生物医学工程系 博士
2007-2014： 汕头大学医学院七年制临床医学（全英班）
工作经历
2023-今：汕头大学医学院第一附属医院神经内科副研究员/主治医师
2020-2022：汕头大学医学院第一附属医院神经内科医师
2014-2015：汕头大学医学院第一附属医院神经内科医师
研究方向
1. 神经组织工程；2. 新型污染物与神经毒理
科研项目
1. 国家自然科学基金青年项目《BMECs修饰三维培养的iPSC-NSPCs促进脊髓损伤后神经环路重塑的作用及机制》
2. 广东省自然科学基金面上项目《M2型小胶质细胞外泌体miR-21-3p调控三维脊髓源性神经干细胞定向分化促进脊髓损伤修复的作用及机制》
3. 广东省基础与应用基础研究基金区域联合基金青年项目《人牙髓干细胞的胞外囊泡通过调控NLRP3炎症小体促进脊髓损伤修复的作用及机制研究》
4. 李嘉诚基金会交叉研究项目《干细胞或外泌体联合微芯片治疗中枢神经系统损伤》
科研论文
1. Wang T, Yi Z, Liu X, Cai Y, Huang X, Fang J, Shen R, Lu W, Xiao Y, Zhuang W, Guo S. Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites. Lancet EBioMedicine, 2024. (IF: 11.1)
2. Wang T, Huang G, Yi Z, Dai S, Zhuang W, Guo S. Advances in extracellular vesicle-based combination therapies for spinal cord injury. Neural Regeneration Research, 2023. (IF: 6.1)
3. Debbi L*, Guo S*, Safina D, Levenberg S. Boosting extracellular vesicle production. Biotechnology Advances, 2022. (IF: 16.0)
4. Guo S*, Debbi L*, Zohar B, Samuel R, Arzi R, Fried A, Carmon T, Shevach D, Redenski I, Schlachet I, Sosnik A, Levenberg S. Stimulating extracellular vesicles production from engineered tissues by mechanical forces. Nano Letters, 2021. (IF: 10.8)
5. Guo S, Redenski I, Levenberg S. Spinal cord repair: from cells and tissue engineering to extracellular vesicles. Cells, 2021. (IF: 6.0)
6. Redenski I*, Guo S*, Machour M, Szklanny A, Landau S, Egozi D, Gabet Y, Levenberg S. Microcomputed Tomography-based analysis of neovascularization within bioengineered vascularized tissues. ACS Biomaterials Science and Engineering, 2021. (IF: 5.8)
7. Redenski I, Guo S, Machour M, Szklanny A, Landau S, Kaplan B, Lock R, Gabet Y, Vunjak-Novakovic G, Levenberg S. Engineered vascularized flaps, composed of polymeric soft-tissue and live-bone, repair complex tibial defects. Advanced Functional Materials, 2021. (IF: 19.0)
8. Frisch A, Debbi L, Shuhmaher M, Guo S, Levenberg S. Advances in vascularization and innervation of constructs for neural tissue engineering. Current Opinion in Biotechnology, 2021. (IF: 7.7)
9. Guo S*, Redenski I*, Landau S, Szklanny A, Merdler U, Levenberg S. Prevascularized scaffolds bearing human dental pulp stem cells for treating complete spinal cord injury. Advanced Healthcare Materials, 2020. (IF: 10.0)
10. Kaplan B, Merdler U, Szklanny A, Redenski I, Guo S, Mucha Z, Michael N, Levenberg S. Rapid prototyping fabrication of soft and oriented polyester scaffolds for axonal guidance. Biomaterials, 2020. (IF: 14.0)
11. Guo S, Perets N, Betzer O, Ben-Shaul S, Sheinin A, Michaelevski I, Popovtzer R, Offen D, Levenberg S. Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury. ACS Nano, 2019. (IF: 17.1)
12. Szklanny A, Debbi L, Merdler U, Neale D, Muniz A, Kaplan B, Guo S, Lahann J, Levenberg S. High-throughput scaffold system for studying the effect of local geometry and topology on the development and orientation of sprouting blood vessels. Advanced Functional Materials, 2019. (IF: 19.0)
13. Landau S, Guo S, Levenberg S. Localization of engineered vasculature within 3D tissue constructs. Frontiers in Bioengineering and Biotechnology, 2018. (IF: 5.7)
14. Ganz J, Shor E, Guo S, Sheinin A, Arie I, Michaelevski I, Pitaru S, Offen D, Levenberg S. Implantation of 3D constructs embedded with oral mucosa-derived cells induces functional recovery in rats with complete spinal cord transection. Frontiers in Neuroscience, 2017. (IF: 4.3)
教学工作
1. 汕头大学医学院《神经学》
2. 汕头大学医学院《医学基础导读》
3. 汕头大学医学院《医学科学推理》
4. 汕头大学工学院生物医学工程系《人体解剖与生理》
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