教育背景
2007.9-2011.7 安徽师范大学 本科
2011.9-2017.3 东华大学 博士
工作经历
2017.1-2019.4 深圳大学 博士后研究员
2019.5-至今 汕头大学工学院生物医学工程系 副教授 硕士生导师
出访及挂职经历
2014.9-2014.10 匈牙利University of Debrecen（交流访问）
2015.5-2015.8 葡萄牙University of Madeira（交流访问）
2017.10-2018.10 美国University of Central Oklahoma（访问学者）
研究方向
新型生物医用材料的设计及其肿瘤诊疗研究
科研项目
1、国家自然科学基金青年基金项目，61805161，基于FLIM/PA复合成像精准监控的二维黑磷纳米片靶向肿瘤化疗和热疗机制研究，2019/01-2021/12，25万元，已结题，已结题，主持；
2、中国博士后科学基金特别资助项目，2018T110890，FLIM/PA成像分析基于黑磷纳米片的癌症精准监控与治疗，15万元，已结题，主持；
3、中国博士后科学基金面上资助项目，2017M622766，FLIM和PA成像精准监控的癌症靶向化疗/热疗方法研究，5万元，已结题，主持；
4、广东省自然科学基金面上项目，2021A1515010441，CD146靶向光热免疫杂化纳米药物的构建及其三阴性乳腺癌精准靶向治疗应用研究，2021/01-2023/12，10万元，在研，主持；
5、汕头大学科研启动经费，09419027，基于二维黑鳞纳米片构建的癌症光热免疫治疗，2019/05-2022/05，120万元，在研，主持；
6、李嘉诚基金会交叉项目，54620305，CD146靶向的光热免疫杂化纳米药物在三阴性乳腺癌精准治疗中的应用研究，2020/07-2023/07，100万元，在研，主持。
科研论文
1. Jinxing Liu,
Chong Zhao, Wei R. Chen, Benqing Zhou*, Recent progress in two-dimensional
nanomaterials for cancer theranostics, Coordination Chemistry Reviews,
2022, 469, 214654 (IF=24.833).
2. Libin Huang,
Chaoran Xie, Zixia Wu, Man Ji, Jia Shan, Pei Cheng, Jianming Liu, Luya Chen,
Benqing Zhou*, Wenjie Sun*, Lateral size homogeneous and doping degree
controllable potassium-doped graphene quantum dots by mechanochemical reaction, Chemical Engineering Journal, 2022, 135800 (IF=16.744).
3. Benqing Zhou,
Jinxing Liu, Meiai Lin, Jingyi Zhu, Wei R. Chen, Recent advances in
immunotherapy, immunoadjuvant, and nanomaterial-based combination
immunotherapy, Coordination Chemistry Reviews, 2021, 442, 214009
(IF=24.833).
4. Benqing Zhou,
Qiang Wu, Meng Wang, Ashley Hoover, Xin Wang, Feifan Zhou, Rheal A. Towner,
Nataliya Smith, Debra Saunders, Jun Song, Junle Qu, Wei R. Chen.
Immunologically modified MnFe2O4 nanoparticles to
synergize photothermal therapy and immunotherapy for cancer treatment, Chemical Engineering Journal, 2020, 396,
125239 (IF=16.744).
5. Benqing Zhou,
Ruizhi Wang, Feng Chen, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai,
Qiang Ouyang, Xiangyang Shi, and Mingwu Shen. 99mTc-labeled
RGD-polyethylenimine conjugates with entrapped gold nanoparticles in the
cavities for dual mode SPECT/CT imaging of hepatic carcinoma, ACS Applied Materials & Interfaces,
2018, 10, 6146-6154 (IF=10.383).
6. Benqing Zhou,
Linfeng Zheng, Chen Peng, Du Li Jingchao Li, Shihui Wen, Mingwu Shen, Guixiang
Zhang, Xiangyang Shi. Synthesis and characterization of PEGylated
polyethylenimine-entrapped gold nanoparticles for blood pool and tumor CT
imaging, ACS Applied Materials &
Interfaces, 2014, 6, 17190-17199 (IF=10.383).
7. Benqing Zhou,
Jinxing Liu, Lu Wang, Meng Wang, Chong Zhao, Haoyu Lin, Yuanke Liang, Rheal A
Towner, Wei R Chen, Iron oxide nanoparticles as a drug carrier reduce host
immunosuppression for enhanced chemotherapy, Nanoscale, 2022,14(12),
4588-4594 (IF=8.307).
8. Benqing Zhou,
Jun Song, Meng Wang, Xin Wang, Jielin Wang, Eric W. Howard, Feifan Zhou, Junle
Qu and Wei R Chen. BSA-bioinspired gold nanorods loaded with immunoadjuvant for
treatment of melanoma by combined photothermal therapy and immunotherapy, Nanoscale, 2018, 10(46),
21640-21647 (IF=8.307).
9. Chong Zhao,
Benqing Zhou*, Polyethyleneimine-Based Drug Delivery Systems for Cancer
Theranostics, Journal of Functional Biomaterials, 2023, 14(1), 12
(IF=4.901).
10. Sheng Zhao,
Liang He, Yihao Sun, Ting Xu, Chunmei Chen, Yi Ouyang, Yan Chen, Yixin Tan,
Benqing Zhou*, Hui Liu*, Acid-responsive drug-loaded copper phosphate
nanoparticles for tumor cell therapy through synergistic apoptosis and
ferroptosis strategy, Journal of Nanoparticle Research, 2023, 25(1), 7
(IF=2.533).
11. Chunmei Chen,
Wei Zhang, Shi-Yu Lu, Jingjing Wang, Yixin Tan, Sheng Zhao, Yi Ouyang, Luen Xu,
Benqing Zhou*, Xuntao Yin*, Haitao Ran*, Hui Liu*, Repolarizing
tumor-associated macrophages by layered double hydroxide-based deacidification
agent for tumor chemodynamic therapy and immunotherapy, Colloids and
Surfaces B: Biointerfaces, 2023, 223, 113157 (IF=5.999).
12. Benqing Zhou, Lingzhou Zhao, Mingwu Shen, Jinhua
Zhao, Xiangyang Shi. A multifunctional polyethylenimine-based nanoplatform for
targeted anticancer drug delivery to tumors in vivo, Journal of Materials Chemistry B, 2017, 5, 1542-1550 (In 2017
Journal of Materials Chemistry B HOT Papers, IF=7.571).
13. Zhe Wang, Yili Zhao, Mingwu Shen, Helena Tomás,
Benqing Zhou*, Xiangyang Shi*, Antitumor Efficacy of Doxorubicin-Loaded
Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers, Journal of Functional Biomaterials, 2022, 13,
55 (IF=4.901).
14. Di Yin, Andrew Shi, Benqing Zhou*, Mengyuan Wang,
Gangwei Xu, Mingwu Shen, Xiaoyue Zhu*, and Xiangyang Shi*, Efficient Capture
and Separation of Cancer Cells Using Hyaluronic Acid-Modified Magnetic Beads in
a Microfluidic Chip, Langmuir, 2022, 38, 36, 11080-11086 (IF=4.331).
15. Jingyi Zhu, Pingping Zhao, Junxing Yang, Jianhui
Shi, Jianlin Chu,Wenjun Miao, Yili Zhao and Benqing Zhou*. Sharpening
upconversion nanoparticles to reduce surface quenching, Dalton Transactions, 2020,49, 285-288 (IF=4.569).
16. Benqing Zhou, Zhijuan Xiong, Peng Wang, Chen Peng,
Mingwu Shen, and Xiangyang Shi. Acetylated Polyethylenimine-Entrapped Gold
Nanoparticles Enable Negative Computed Tomography Imaging of Orthotopic Hepatic
Carcinoma, Langmuir, 2018, 34 (29),
8701-8707 (IF=4.331).
17. Benqing Zhou, Zuogang Xiong, Jianzhi Zhu, Mingwu
Shen, Guangyu Tang, Chen Peng, Xiangyang Shi. PEGylated
polyethylenimine-entrapped gold nanoparticles loaded with gadolinium for dual
mode CT/MR imaging applications, Nanomedicine,
2016, 11(13), 1639-1652 (IF=6.096).
18. Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng,
Mingwu Shen, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi. Targeted tumor
dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold
nanoparticles loaded with gadolinium, Drug
Delivery, 2018, 25(1), 178-186 (IF=6.891).
19. Benqing Zhou, Mingwu Shen, István Bányai,
Xiangyang Shi. Structural characterization of PEGylated
polyethylenimine-entrapped gold nanoparticles: an NMR study, Analyst, 2016, 141, 5390-5397
(IF=5.227).
20. Benqing Zhou, Jia Yang, Chen Peng, Jianzhi Zhu,
Yueqin Tang, Xiaoyue Zhu, Mingwu Shen, Guixiang Zhang, Xiangyang Shi. PEGylated
polyethylenimine-entrapped gold nanoparticles modified with folic acid for
targeted tumor CT imaging, Colloids and
Surfaces B: Biointerfaces, 2016, 140, 489-496 (IF=5.999).
21. Rania Mustafa#, Benqing Zhou#,
Jia Yang#, Guixiang Zhang, Xiangyang Shi. Dendrimer-functionalized
laponite nanodisks loaded with gadolinium for T1-weighted MR imaging
applications, RSC Advances, 2016, 6,
95112-95119 (IF=4.036).
22. Fanfan Fu#, Benqing Zhou#,
Zhijun Ouyang, Yilun Wu, Jingyi Zhu, Mingwu Shen, Jindong Xia, Xiangyang Shi,
Multifunctional cholesterol-modified dendrimers for targeted drug delivery to
cancer cells expressing folate receptors, Chinese
Journal of Polymer Science, 2019, 37(2), 129-135 (IF=3.815).
23. Xin Yuan, Benqing Zhou*, Maoquan Li, Mingwu Shen
and Xiangyang Shi*, Colorimetric detection of Cr3+ ions in aqueous
solution using poly(γ-glutamic acid)-stabilized gold nanoparticles, Analytical
Methods, 2020, 12, 3145-3150 (IF=3.532).
专利
1. 史向阳，周本青，彭琛，张贵祥，郑林丰，一种聚乙二醇化修饰的超支化聚乙烯亚胺包裹纳米金颗粒的制备方法，中国发明专利，专利号：ZL201310193203.2授权公告日：2015-05-13（已授权）。
2. 史向阳，周本青，张贵祥，杨嘉，彭琛，一种叶酸靶向的多功能超支化聚乙烯亚胺包裹金纳米颗粒的制备方法，中国发明专利，专利号：ZL2014104876861.1授权公告日：2017-01-04（已授权）。
3. 史向阳，孙文杰，朱建志，李静超，周本青，沈明武，一种负载氧化铁纳米颗粒的海藻酸钠纳米凝胶的制备方法，中国发明专利，专利号：ZL 201510023466.8授权公告日：2017-10-24（已授权）。
4. 史向阳，陈晨，周本青，一种透明质酸靶向的多功能支化聚乙烯亚胺药物载体的制备方法，中国发明专利，专利号：ZL201510487046.5授权公告日：2018-04-20（已授权）。
5. 史向阳，周一伟，周本青，孙文杰，胡勇，一种负载聚苯胺的γ‑PGA纳米水凝胶的制备方法，中国发明专利，专利号：ZL2017100767290，授权公告日：2020-04-21（已授权）。
6. 史向阳，王鹏，胡勇，周本青，徐凡丽，张贵祥，杨嘉，一种两性离子修饰的多功能Mn3O4纳米颗粒磁共振成像造影剂及其制备和应用，中国发明专利，专利号：ZL
2016108885337，授权公告日：2020-05-29（已授权）。
7. 周本青，赵冲，一种基于PEG-MAL修饰的靶向HER2阳性乳腺癌的二维黑磷杂化纳米药物，中国发明专利，专利号：202210413458.4，授权公告日：2020.06.09（已授权）。
8. 史向阳，周本青，一种基于RGD多肽修饰的超支化聚乙烯亚胺纳米探针的制备方法，中国发明专利，申请号：201710136134X，申请日期：2017-03-08。
9. 史向阳，朱建志，孙文杰，周本青，周一伟，彭琛，一种负载Au纳米颗粒的γ-PGA水凝胶中的制备方法，中国发明专利，申请号：201610068698X，申请日期：2016-01-29。
10. 史向阳，周本青，汤光宇，彭琛，付繁繁，一种基于超支化聚乙烯亚胺分子的CT/MR双模态成像造影剂的制备方法，中国发明专利，申请号：2014104689140，申请日期：2014-09-15。
11. 史向阳，周本青，赵晋华，赵凌舟，一种叶酸靶向的多功能超支化聚乙烯亚胺负载阿霉素的方法，中国发明专利，申请号：2016104209250，申请日期：2015-06-14。
12. 周本青，刘锦杏，一种基于OVA蛋白修饰的氧化铁锰杂化纳米药物与制备方法，中国发明专利，申请号：2020101180596，申请日期：2020.02.26。
13. 周本青，刘锦杏，赵冲，一种基于Calcein
AM/PI双染细胞荧光图像的细胞计数方法，中国发明专利，申请号：202210698019.2，申请日期：2022.06.20。
教学工作
1. 本科生教学科目：Design
and Application of Biomaterials、Physics for Biomedical Engineering（热力学部分）、Biomedical
Undergraduate Lab（细胞实验部分）
2. 研究生教学科目：生物医药工程前沿进展
学术兼职
担任Journal of Functional Biomaterials（IF=4.8, JCR-Q2）的Editorial Board Member
荣誉奖励
2021年汕头大学优秀党员
2022年汕头大学优秀班主任
2023指导大学生获得第九届中国国际“互联网+”大学生创新创业大赛广东省分赛铜奖
